The first pullback after the news breaks is crucial: if the price holds, it suggests buying pressure is still strong.
Take this transaction, for example: an address belonging to Wang Chun, co-founder of F2Pool, sold 235.5 WBTC for ETH.
I'm going to compare the activity of large holders' addresses before and after the news broke.
$WBTC, down 1.22% over 24h.

#WBTC

In a highly volatile market, risk management comes first.